Arizona Cardinals at San Francisco 49ers -- NFL Week 3, September 27, 2026.
Model prediction: San Francisco 49ers favored by 13.2, projected total 56.7 points, 80.7% win probability for San Francisco 49ers.
Prediction last recalculated August 30, 2026 at 6:00 AM UTC.
Market spread: San Francisco 49ers -11.5.
Simulated range of outcomes (10,000 simulations) -- home margin 10th percentile: -4.2, 25th percentile: +3.9, 50th percentile: +13.2, 75th percentile: +22.2, 90th percentile: +30.2. Total points 10th percentile: 39.4, 25th percentile: 47.8, 50th percentile: 57.1, 75th percentile: 66.2, 90th percentile: 74.2.
SF predicted starting offense vs ARI's Base 4-3 D: WR Mike Evans, WR Deebo Samuel, LT Trent Williams, LG Robert Jones, C Jake Brendel, RG Dominick Puni, RT Colton McKivitz, WR De'Zhaun Stribling, QB Brock Purdy, TE George Kittle, TE Jake Tonges, RB Christian McCaffrey, FB Kyle Juszczyk.
ARI predicted starting offense vs SF's Base 3-4 D: WR Marvin Harrison, WR Michael Wilson, LT Paris Johnson, LG Isaac Seumalo, C Hjalte Froholdt, RG Isaiah Adams, RT Elijah Wilkinson, WR Kendrick Bourne, QB Jacoby Brissett, TE Trey McBride, TE Tip Reiman, RB Jeremiyah Love.
ARI's offensive depth chart isn't fully set yet (12/13 slots known). SF leans pass-heavy (63% of recent snaps) against ARI's Base 4-3 D. ARI leans pass-heavy (75% of recent snaps) against SF's Base 3-4 D.
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