Miami Dolphins at San Francisco 49ers -- NFL Week 2, September 20, 2026.
Model prediction: San Francisco 49ers favored by 7.6, projected total 45.6 points, 69.5% win probability for San Francisco 49ers.
Prediction last recalculated August 30, 2026 at 6:00 AM UTC.
Market spread: San Francisco 49ers -10.5.
Simulated range of outcomes (10,000 simulations) -- home margin 10th percentile: -9.7, 25th percentile: -1.5, 50th percentile: +7.5, 75th percentile: +16.2, 90th percentile: +24.4. Total points 10th percentile: 28.4, 25th percentile: 36.7, 50th percentile: 45.9, 75th percentile: 54.7, 90th percentile: 63.2.
SF predicted starting offense vs MIA's Base 4-3 D: WR Mike Evans, WR Deebo Samuel, LT Trent Williams, LG Robert Jones, C Jake Brendel, RG Dominick Puni, RT Colton McKivitz, WR De'Zhaun Stribling, QB Brock Purdy, TE George Kittle, TE Jake Tonges, RB Christian McCaffrey, FB Kyle Juszczyk.
MIA predicted starting offense vs SF's Base 3-4 D: WR Malik Washington, WR Jalen Tolbert, LT Patrick Paul, LG Kadyn Proctor, C Aaron Brewer, RG Jonah Savaiinaea, RT Austin Jackson, WR Caleb Douglas, QB Malik Willis, TE Greg Dulcich, TE Will Kacmarek, RB Devon Achane, FB Ben Sims.
SF leans pass-heavy (63% of recent snaps) against MIA's Base 4-3 D.
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