San Francisco 49ers at Los Angeles Rams -- NFL Week 1, September 11, 2026.
Model prediction: Los Angeles Rams favored by 5.7, projected total 62.2 points, 65.0% win probability for Los Angeles Rams.
Prediction last recalculated August 30, 2026 at 6:00 AM UTC.
Market spread: Los Angeles Rams -3.5.
Simulated range of outcomes (10,000 simulations) -- home margin 10th percentile: -11.5, 25th percentile: -3.3, 50th percentile: +5.6, 75th percentile: +14.7, 90th percentile: +22.5. Total points 10th percentile: 44.7, 25th percentile: 53.0, 50th percentile: 62.2, 75th percentile: 71.4, 90th percentile: 79.3.
LA predicted starting offense vs SF's Base 3-4 D: WR Puka Nacua, WR Davante Adams, LT Alaric Jackson, LG Steve Avila, C Coleman Shelton, RG Kevin Dotson, RT Warren McClendon, WR Jordan Whittington, QB Matthew Stafford, TE Colby Parkinson, TE Tyler Higbee, RB Kyren Williams.
SF predicted starting offense vs LA's Base 3-4 D: WR Mike Evans, WR Deebo Samuel, LT Trent Williams, LG Robert Jones, C Jake Brendel, RG Dominick Puni, RT Colton McKivitz, WR De'Zhaun Stribling, QB Brock Purdy, TE George Kittle, TE Jake Tonges, RB Christian McCaffrey, FB Kyle Juszczyk.
LA's offensive depth chart isn't fully set yet (12/13 slots known). LA leans pass-heavy (65% of recent snaps) against SF's Base 3-4 D. SF leans pass-heavy (63% of recent snaps) against LA's Base 3-4 D.
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